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Pharmacology - Blood and Blood Products (24314122 (Tutorial) QID: 12076)

A. "If a client should develop crackles in their lung fields, it is a sign of a hemolytic reaction."

B. “Transfusion-related graft versus host disease most commonly occurs in immuno-suppressed individuals.”

C. “Transfusion-associated circulatory overload (TACO) is more common in clients with renal failure.”

D. “It is important to ask the client about history of previous blood transfusions.”

E. “Pre-medication with diphenhydramine and acetaminophen is always needed before transfusion.”


Statistics

Difficulty level - Medium
1/2Avg. Peers Score
Time taken - 48 s

Subject/Lesson

  • Subject

    Pharmacology
  • Lesson

    Blood and Blood Products

Client Need

  • Test Plan

    Pharmacological and Parenteral Therapies
  • Related Topic

    Blood and Blood Products

Item Type

  • Item Type

    Analysis

Explanation

Choice A is correct. Crackles in the lung fields suggest a transfusion-associated circulatory overload (TACO). This statement requires correction because it is not correct.

Choice E is correct. Physicians may prescribe pre-medication with diphenhydramine and acetaminophen only if the client has a history of febrile or allergic reactions to prior blood transfusions. Pre-medications are, therefore, not always required.

Choice B is incorrect. Graft-versus-host-disease (GVHD) is a rare transfusion reaction that occurs mostly in severely immunocompromised clients (post-bone-marrow transplant, Hodgkin disease, non-Hodgkin lymphoma, and acute myeloid and acute lymphoid leukemias). In this condition, the donor's T lymphocytes cause an immune response in the recipient by engrafting in the recipient's marrow and attacking the recipient's tissues/blood cells. Under normal circumstances, donor T-cells are killed by the recipient's immune system, but in severe immunodeficiency, donor T-cells remain, causing GVHD. Transfusion-related GVHD presents with fever, rash all over, including feet and hands, diarrhea, nausea, and elevated Liver function tests. Such reactions can be limited by a process called “Cytoreduction,” where the T-cells are removed from the donor blood products.

Choice C is incorrect. Transfusion Associated Circulatory Overload (TACO) is more common in patients with baseline cardiac and renal disorders. Fluid overload can happen during transfusion if the client already has underlying congestive heart failure. If the client is felt to be at risk for circulatory overload, a loop diuretic such as furosemide may be ordered before, after, or in between PRBC units.

Choice D is incorrect. It is important to get a history of previous blood transfusions as the nurse can take action before the transfusion to pre-medicate the client, as prescribed.

Related Videos

2 Key Topics

Additional Info

Source : Archer Review

The nurse should remain with the client during a transfusion's first fifteen to thirty minutes to observe for a hemolytic or allergic reaction.

➢ A hemolytic blood transfusion may be fatal if not caught promptly. The primary cause of this reaction is the misidentification of the client and the blood product.

➢ Manifestations of a hemolytic reaction include low-back pain, chest pain, tachycardia, hypotension, and a feeling of impending doom.

➢ If a hemolytic reaction is assessed, the nurse should immediately discontinue the transfusion and save the tubing and unit of blood for further analysis.

➢ Immediate client care involves spiking a new bag of isotonic saline (with new tubing) and keeping the intravenous catheter patent.

Last Updated - 19 Dec 2023